Synvisc-One is an injectable arthritis gel made from a substance called hyaluronan, which is harvested from the fleshy crest on chickens’ heads called chicken combs. The human body also contains hyaluronan.
The U.S. Food and Drug Administration approved the gel injection in 2009 to treat osteoarthritis of the knee in people who cannot manage their pain without medication or with pain relievers like acetaminophen. Sanofi Genzyme makes the medication.
What can Synvisc-one be used for?
SYNVISC can be used to effectively treat osteoarthritis knee joint pain where the existing lubricant is not enough to act as a barrier during knee movements. Synvisc contains the long chain polymer, hyaluronan which once injected begins to lubricate and cushion the knee joint, eliminating all pain. Hyaluronic is unique due to its repetitive units of disaccharides.
SYNVISC® (hylan G-F 20) contains both hylan A and hylan B polymers which are derived from chicken combs. Hylans are derivatives of hyaluronan (sodiumhyaluronate). Hylan G-F 20 is highly effective due to its chemically crosslinkage.
Who should not use Synvisc-one?
Anyone with allergies to hyaluronan and anyone with a knee or skin infection at the proposed site of injection.
More importantly, anyone with allergies to birds and bird products, such as feathers, eggs and bird meat.
Breastfeeding and pregnant women should not use Synvisc-One.
What is the administration process for Synvisc?
SYNVISC is injected directly into the knee over the course of three doctor visits, one week apart. It’s a simple, in-office procedure that takes just a few minutes.
Both knees can be treated in the same session.
Following treatment, care should be taken not to carry out any heavy lifting. Your strength will start to build up again after 2 days.
What are the associated side effects with Synvisc?
With SYNVISC being administered into the knee joint, and not into the blood, there is much less likely to be any side effects. However, swelling, pain and excess fluid were reported in 7% patients. Rash and Hives have also been reported in some cases.
When will I see results with Synvisc?
Results can be felt immediately. However, at least 3 injections are required to feel the full optimum effects of the treatment. With each individual case being different, many patients start to see pain relief after 2 months after the initial injection. Long term relief following all three injections can last half a year. The advantages are that Synvisc can be repeatedly used following the advice of a medical professional.
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